产品名称
EST3 Rabbit Polyclonal Antibody
别名
Carboxylesterase 3 (EC 3.1.1.1) (Liver carboxylesterase 31 homolog)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.193% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23491
Human Swissprot No.
Q6UWW8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6UWW8/entry
免疫原
Synthesized peptide derived from human EST3 AA range: 447-497
特异性
This antibody detects endogenous levels of EST3 at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010],
组织表达
Expressed in liver, colon and small intestine.
细胞定位
Endoplasmic reticulum lumen .
功能
catalytic activity:A carboxylic ester + H(2)O = an alcohol + a carboxylate.,function:Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.,PTM:N-glycosylated.,similarity:Belongs to the type-B carboxylesterase/lipase family.,tissue specificity:Expressed in liver, colon and small intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
