产品名称
UBA2 Rabbit Polyclonal Antibody
别名
UBA2; SAE2; UBLE1B; HRIHFB2115; SUMO-activating enzyme subunit 2; Anthracycline-associated resistance ARX; Ubiquitin-like 1-activating enzyme E1B
蛋白名称
SUMO-activating enzyme subunit 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10054
Human Swissprot No.
Q9UBT2
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UBT2/entry
Mouse Swissprot No.
Q9Z1F9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z1F9
免疫原
The antiserum was produced against synthesized peptide derived from human Uba2. AA range:591-640
特异性
UBA2 Polyclonal Antibody detects endogenous levels of UBA2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010],
组织表达
Brain,Cervix carcinoma,Fetal brain,Placenta,Skin,Testis,
细胞定位
Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.
信号通路
Ubiquitin mediated proteolysis;
功能
function:The dimeric enzyme acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2.,pathway:Protein modification; protein sumoylation.,similarity:Belongs to the ubiquitin-activating E1 family.,subunit:Heterodimer of SAE1 and SAE2. The complex binds SUMO proteins via SAE2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
