产品名称
GALT2 Rabbit Polyclonal Antibody
别名
Polypeptide N-acetylgalactosaminyltransferase 2 (EC 2.4.1.41) (Polypeptide GalNAc transferase 2) (GalNAc-T2) (pp-GaNTase 2) (Protein-UDP acetylgalactosaminyltransferase 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form]
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.194% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2590
Human Swissprot No.
Q10471
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q10471/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/108148
Mouse Swissprot No.
Q6PB93
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6PB93
免疫原
Synthesized peptide derived from human GALT2 AA range: 30-80
特异性
This antibody detects endogenous levels of GALT2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
细胞定位
Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein . Secreted . Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.
功能
catalytic activity:UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide.,cofactor:Calcium.,cofactor:Manganese.,domain:The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.,domain:There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.,function:Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.,online information:GlycoGene database,online information:Polypeptide N-acetylgalactosaminyltransferase 2,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.,similarity:Contains 1 ricin B-type lectin domain.,subcellular location:Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
