产品名称
TUTase Rabbit Polyclonal Antibody
别名
TUT1; RBM21; Speckle targeted PIP5K1A-regulated poly(A) polymerase; Star-PAP; RNA-binding motif protein 21; RNA-binding protein 21; U6 snRNA-specific terminal uridylyltransferase 1; U6-TUTase
蛋白名称
Speckle targeted PIP5K1A-regulated poly(A) polymerase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64852
Human Swissprot No.
Q9H6E5
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9H6E5/entry
Mouse Swissprot No.
Q8R3F9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R3F9
免疫原
The antiserum was produced against synthesized peptide derived from human TUT1. AA range:291-340
特异性
TUTase Polyclonal Antibody detects endogenous levels of TUTase protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a nucleotidyl transferase that functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase. The encoded enzyme specifically adds and removes nucleotides from the 3' end of small nuclear RNAs and select mRNAs and may function in controlling gene expression and cell proliferation.[provided by RefSeq, Apr 2009],
细胞定位
Nucleus, nucleolus . Nucleus speckle .
功能
catalytic activity:UTP + RNA(n) = diphosphate + RNA(n+1).,function:Highly specific terminal uridylyltransferase that exclusively accepts U6 snRNA as substrate. U6 snRNA is unique in that nucleotides are both added to and removed from its 3'-end. U6-TUTase is responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RRM (RNA recognition motif) domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
