产品名称
TTK Rabbit Polyclonal Antibody
别名
TTK; MPS1; MPS1L1; Dual specificity protein kinase TTK; Phosphotyrosine picked threonine-protein kinase; PYT
蛋白名称
Dual specificity protein kinase TTK
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7272
Human Swissprot No.
P33981
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P33981/entry
Mouse Swissprot No.
P35761
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P35761
免疫原
The antiserum was produced against synthesized peptide derived from human TTK. AA range:642-691
特异性
TTK Polyclonal Antibody detects endogenous levels of TTK protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
TTK protein kinase(TTK) Homo sapiens This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009],
组织表达
Present in rapidly proliferating cell lines.
细胞定位
kinetochore,cytoplasm,spindle,membrane,
信号通路
Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,tissue specificity:Present in rapidly proliferating cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
