BD-PT4770

TTF-1 Rabbit Polyclonal Antibody

NKX2-1; NKX2A; TITF1; TTF1; Homeobox protein Nkx-2.1; Homeobox protein NK-2 homolog A; Thyroid nuclear factor 1; Thyroid transcription factor 1; TTF-1

常规抗体

NKX2-1

Homeobox protein Nkx-2.1

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

7080

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7080

P43699

http://www.uniprot.org/uniprotkb/P43699/entry

21869

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21869

P50220

http://www.uniprot.org/uniprot/P50220

P23441

http://www.uniprot.org/uniprot/P23441

The antiserum was produced against synthesized peptide derived from human TTF-1. AA range:27-76

TTF-1 Polyclonal Antibody detects endogenous levels of TTF-1 protein.

WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

38kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014],

Thyroid and lung.

Nucleus .

disease:Defects in NKX2-1 are the cause of benign hereditary chorea (BHC) [MIM:118700]; also known as hereditary chorea without dementia. BHC is an autosomal dominant movement disorder. The early onset of symptoms (usully before the age of 5) and the observation that in some BHC families the symptoms tend to decrease in adulthood suggests that the disorder results from a developmental disturbance of the brain. BHC is non-progressive and patients have normal or slightly below normal intelligence. There is considerable inter- and intrafamilial variability, including dysarthria, axial distonia and gait disturbances.,disease:Defects in NKX2-1 are the cause of choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD) [MIM:610978]. This syndrome include neurological, thyroid, and respiratory problems.,function:Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis.,PTM:Phosphorylated on serine residues.,similarity:Belongs to the NK-2 homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Thyroid and lung.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.