产品名称
TSC-22 Rabbit Polyclonal Antibody
别名
TSC22D1; KIAA1994; TGFB1I4; TSC22; hucep-2; TSC22 domain family protein 1; Cerebral protein 2; Regulatory protein TSC-22; TGFB-stimulated clone 22 homolog; Transforming growth factor beta-1-induced transcript 4 protein
蛋白名称
TSC22 domain family protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8848
Human Swissprot No.
Q15714
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q15714/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21807
Mouse Swissprot No.
P62500
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P62500
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=498545
Rat Swissprot Link
http://www.uniprot.org/uniprot/P62501
免疫原
The antiserum was produced against synthesized peptide derived from human TSC22D1. AA range:71-120
特异性
TSC-22 Polyclonal Antibody detects endogenous levels of TSC-22 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011],
组织表达
Widely expressed in fetal and adult tissues.
细胞定位
Cytoplasm . Nucleus .
功能
function:Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.,induction:In aortic endothelial cells, induced by cytokines, including TGFB.,similarity:Belongs to the TSC-22/Dip/Bun family.,subunit:Homodimer or heterodimer. Can form an heterodimer with TSC22D4.,tissue specificity:Widely expressed in fetal and adult tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
