产品名称
TRα Rabbit Polyclonal Antibody
别名
THRA; EAR7; ERBA1; NR1A1; THRA1; THRA2; Thyroid hormone receptor alpha; Nuclear receptor subfamily 1 group A member 1; V-erbA-related protein 7; EAR-7; c-erbA-1; c-erbA-alpha
蛋白名称
Thyroid hormone receptor alpha
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7067
Human Swissprot No.
P10827
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P10827/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21833
Mouse Swissprot No.
P63058
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P63058
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81812
Rat Swissprot Link
http://www.uniprot.org/uniprot/P63059
免疫原
The antiserum was produced against synthesized peptide derived from human Thyroid Hormone Receptor alpha. AA range:10-59
特异性
TRα Polyclonal Antibody detects endogenous levels of TRα protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
组织表达
Brain,Brain cortex,Hippocampus,Kidney,Muscle,Testis,
细胞定位
Nucleus.; [Isoform Alpha-2]: Cytoplasm . Nucleus . When overexpressed found in the cytoplasm where it colocalizes with TACC1. .
信号通路
Neuroactive ligand-receptor interaction;
功能
domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,function:Nuclear hormone receptor. High affinity receptor for triiodothyronine.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with C1D (By similarity). Interacts with AKAP13.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
