BD-PT4752

TrxR2 Rabbit Polyclonal Antibody

TXNRD2; KIAA1652; TRXR2; Thioredoxin reductase 2; mitochondrial; Selenoprotein Z; SelZ; TR-beta; Thioredoxin reductase TR3

常规抗体

TXNRD2

Thioredoxin reductase 2 mitochondrial

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

10587

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10587

Q9NNW7

http://www.uniprot.org/uniprotkb/Q9NNW7/entry

26462

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26462

Q9JLT4

http://www.uniprot.org/uniprot/Q9JLT4

50551

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50551

Q9Z0J5

http://www.uniprot.org/uniprot/Q9Z0J5

The antiserum was produced against synthesized peptide derived from human TRXR2. AA range:471-520

TrxR2 Polyclonal Antibody detects endogenous levels of TrxR2 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

56kD

-20°C/1 year

Polyclonal, Rabbit,IgG

thioredoxin reductase 2(TXNRD2) Homo sapiens This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013],

Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low. High expression is observed in the adrenal cortex (PubMed:24601690).

Mitochondrion .

Pyrimidine metabolism;

catalytic activity:Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.,cofactor:FAD.,function:Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.,miscellaneous:The active site is a redox-active disulfide bond. The selenocysteine residue is essential for enzymatic activity.,sequence caution:Translated as Sec.,similarity:Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.,subunit:Homodimer.,tissue specificity:Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614 levels are low.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.