产品名称
TROP-2 Rabbit Polyclonal Antibody
别名
TACSTD2; GA733-1; M1S1; TROP2; Tumor-associated calcium signal transducer 2; Cell surface glycoprotein Trop-2; Membrane component chromosome 1 surface marker 1; Pancreatic carcinoma marker protein GA733-1
蛋白名称
Tumor-associated calcium signal transducer 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4070
Human Swissprot No.
P09758
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P09758/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56753
Mouse Swissprot No.
Q8BGV3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BGV3
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=494343
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q6P9Z6
免疫原
The antiserum was produced against synthesized peptide derived from human TACD2. AA range:131-180
特异性
TROP-2 Polyclonal Antibody detects endogenous levels of TROP-2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009],
组织表达
Placenta, pancreatic carcinoma cell lines.
细胞定位
Membrane; Single-pass type I membrane protein.
功能
disease:Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD) [MIM:204870]; also known as lattice corneal dystrophy type III. GDLD is an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment.,function:GA733 tumor-associated antigen gene family may function as growth factor receptors.,PTM:The N-terminus is blocked.,similarity:Contains 1 thyroglobulin type-1 domain.,tissue specificity:Placenta, pancreatic carcinoma cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
