产品名称
TRIM3 Rabbit Polyclonal Antibody
别名
TRIM3; BERP; RNF22; RNF97; Tripartite motif-containing protein 3; Brain-expressed RING finger protein; RING finger protein 22; RING finger protein 97
蛋白名称
Tripartite motif-containing protein 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10612
Human Swissprot No.
O75382
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O75382/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55992
Mouse Swissprot No.
Q9R1R2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9R1R2
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83616
Rat Swissprot Link
http://www.uniprot.org/uniprot/O70277
免疫原
The antiserum was produced against synthesized peptide derived from human TRIM3. AA range:1-50
特异性
TRIM3 Polyclonal Antibody detects endogenous levels of TRIM3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008],
组织表达
Expressed in brain, heart, uterus and testis.
细胞定位
Cytoplasm . Early endosome . Golgi apparatus, trans-Golgi network . Cell projection, dendrite .
功能
domain:The interaction with myosin V is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades.,similarity:Belongs to the TRIM/RBCC family.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 filamin repeat.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 6 NHL repeats.,subunit:Associates with myosin V and alpha-actinin-4 (ACTN4).,tissue specificity:Expressed in brain, heart, uterus and testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
