产品名称
AP1B1 Rabbit Polyclonal Antibody
别名
AP-1 complex subunit beta-1 (Adapter-related protein complex 1 subunit beta-1) (Adaptor protein complex AP-1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)
基因名称
AP1B1 ADTB1 BAM22 CLAPB2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.201% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/162
Human Swissprot No.
Q10567
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q10567/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/11764
Mouse Swissprot No.
O35643
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O35643
Rat Gene Link
https://www.uniprot.org/uniprot/29663
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P52303
免疫原
Synthesized peptide derived from human AP1B1 AA range: 215-265
特异性
This antibody detects endogenous levels of AP1B1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],
细胞定位
Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
功能
disease:Deletion of the AP1B1 gene may play a role in the tumorigenesis of meningiomas.,function:Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.,similarity:Belongs to the adaptor complexes large subunit family.,subcellular location:Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.,subunit:Adaptor protein complex 1 (AP-1) is an heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
