BD-PT4717

TRAF2 Rabbit Polyclonal Antibody

TRAF2; TRAP3; TNF receptor-associated factor 2; E3 ubiquitin-protein ligase TRAF2; Tumor necrosis factor type 2 receptor-associated protein 3

常规抗体

TRAF2

TNF receptor-associated factor 2

WB

Human,Rat,Mouse,,Bovine

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

7186

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7186

Q12933

http://www.uniprot.org/uniprotkb/Q12933/entry

P39429

http://www.uniprot.org/uniprot/P39429

Synthesized peptide derived from the Internal region of human TRAF2.

TRAF2 Polyclonal Antibody detects endogenous levels of TRAF2 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

60kD

-20°C/1 year

Polyclonal, Rabbit,IgG

TNF receptor associated factor 2(TRAF2) Homo sapiens The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this pro

Brain,Cerebellum,Colon,Fetal brain,Human endometrium,Kidney,Leukocyte,Splee

Cytoplasm .

MAPK_ERK_Growth;MAPK_G_Protein;Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;RIG-I-like receptor;Adipocytokine;Pathways in cancer;Small cell lung cancer;

domain:The coiled coil domain mediates homo- and hetero-oligomerization.,domain:The MATH/TRAF domain binds to receptor cytoplasmic domains.,function:Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Association to the receptor is also mediated by the interaction with TRADD. Mediates activation of NF-kappa-B and JNK and is involved in apoptosis. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. Seems to be involved in IL-15 signaling.,PTM:Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation. Not ubiquitinated by SIAH1.,similarity:Contains 1 MATH domain.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 2 TRAF-type zinc fingers.,subunit:Homotrimer (Probable). Heteromer with TRAF1. Binds to TNFRSF1B/TNFR2, TNFRSF4 and TNFRSF5/CD40. Associates with CD27, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13B/TACI. TNFRSF14, TNFRSF16/NGFR, TNFRSF17/BCMA, TNFRSF18/AITR, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, IL15RA, TANK/ITRAF, RIPK2, TNIK, MAP3K14, MAP3K5, MAP3K1, MAP4K2, CDK9, CSK, and TRAF-interacting protein TRAIP and TRAF and TNF receptor associated protein TTRAP. Interacts with TNFAIP3 and TRPC4AP. Interacts with PEG3 (By similarity). Binds to TRADD. Interacts with BIRC2 and BIRC3 N-terminus. Interacts with CYLD and TBK1. Interacts with MAVS/IPS1. Interacts with CASP8AP2 and USP48. Interacts with DAB2IP. Interacts wtih NFATC2IP and with HIVEP3.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.