BD-PT4695

Tollip Rabbit Polyclonal Antibody

TOLLIP; Toll-interacting protein

常规抗体

TOLLIP

Toll-interacting protein

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

54472

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54472

Q9H0E2

http://www.uniprot.org/uniprotkb/Q9H0E2/entry

Q9QZ06

http://www.uniprot.org/uniprot/Q9QZ06

Synthesized peptide derived from the Internal region of human Tollip.

Tollip Polyclonal Antibody detects endogenous levels of Tollip protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

30kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016],

Brain,Eye,Placenta,Testis,

Cytoplasm .

Toll_Like;

function:Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity.,PTM:Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products.,similarity:Contains 1 CUE domain.,subunit:Oligomerizes. Binds to TLR2 and the TLR4-MD2 complex via its C-terminus. Exists as complex with IRAK1 in unstimulated cells. Upon IL-1 signaling, Tollip binds to the activated IL-1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. Interacts with TOM1L2.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.