产品名称
TNNI3K Rabbit Polyclonal Antibody
别名
TNNI3K; CARK; Serine/threonine-protein kinase TNNI3K; Cardiac ankyrin repeat kinase; Cardiac troponin I-interacting kinase; TNNI3-interacting kinase
蛋白名称
Serine/threonine-protein kinase TNNI3K
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51086
Human Swissprot No.
Q59H18
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q59H18/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=435766
Mouse Swissprot No.
Q5GIG6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q5GIG6
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=295531
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q7TQP6
免疫原
The antiserum was produced against synthesized peptide derived from human TNNI3K. AA range:301-350
特异性
TNNI3K Polyclonal Antibody detects endogenous levels of TNNI3K protein.
稀释度
WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:10000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology. [provided by RefSeq, Sep 2012],
组织表达
Highly expressed in both adult and fetal heart.
细胞定位
Nucleus . Cytoplasm . Expressed at lower levels in the cytoplasm.
信号通路
Fructose and mannose metabolism;Amino sugar and nucleotide sugar metabolism;
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,catalytic activity:GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose.,cofactor:Magnesium.,function:Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.,function:May play a role in cardiac physiology.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 10 ANK repeats.,subcellular location:Expressed at lower levels in the cytoplasm.,subunit:Interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, BABP3 and HADHB.,tissue specificity:Expressed in many tissues.,tissue specificity:Highly expressed in both adult and fetal heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
