BD-PT4691

TNF-β Rabbit Polyclonal Antibody

LTA; TNFB; TNFSF1; Lymphotoxin-alpha; LT-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1

常规抗体

LTA

Lymphotoxin-alpha

WB

Human,Mouse,Rat,Monkey

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

4049

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4049

P01374

http://www.uniprot.org/uniprotkb/P01374/entry

16992

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16992

P09225

http://www.uniprot.org/uniprot/P09225

25008

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25008

Q06332

http://www.uniprot.org/uniprot/Q06332

The antiserum was produced against synthesized peptide derived from human TNF-beta. AA range:17-66

TNF-β Polyclonal Antibody detects endogenous levels of TNF-β protein.

WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

22kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012],

Lymph,Peripheral blood leukocyte,Peripheral blood mononuclear cells,Peripheral blood mononu

Secreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated.

Cytokine-cytokine receptor interaction;Antigen processing and presentation;Type I diabetes mellitus;

disease:Genetic variations in LTA are associated with susceptibility to leprosy type 4 (LPRS4) [MIM:610988]; also known as susceptibility to age-dependent leprosy. Leprosy is a chronic infectious disease of peripheral sensory nerves caused by Mycobacterium leprae.,disease:Genetic variations in LTA are associated with susceptibility to psoriatic arthritis [MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. Psoriatic arthritis has been defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative arthritis) associated with psoriasis.,function:Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.,online information:Lymphotoxin entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the tumor necrosis factor family.,subcellular location:The homotrimer is secreted. The heterotrimer is membrane-associated.,subunit:Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.