产品名称
TNF-R2 Rabbit Polyclonal Antibody
别名
TNFRSF1B; TNFBR; TNFR2; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; CD antigen CD120b; Etanercept
蛋白名称
Tumor necrosis factor receptor superfamily member 1B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7133
Human Swissprot No.
P20333
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P20333/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21938
Mouse Swissprot No.
P25119
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P25119
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=156767
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q80WY6
免疫原
The antiserum was produced against synthesized peptide derived from human TNF Receptor II. AA range:376-425
特异性
TNF-R2 Polyclonal Antibody detects endogenous levels of TNF-R2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008],
细胞定位
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Tumor necrosis factor-binding protein 2]: Secreted.
信号通路
Cytokine-cytokine receptor interaction;Adipocytokine;Amyotrophic lateral sclerosis (ALS);
功能
function:Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.,online information:Clinical information on Enbrel,pharmaceutical:Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe rheumatoid arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an immunoglobulin Fc chain. It binds to TNF-alpha and blocks its interactions with receptors.,PTM:A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.,PTM:Phosphorylated; mainly on serine residues and with a very low level on threonine residues.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Binds to TRAF2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
