BD-PT4682

TMPRSS3 Rabbit Polyclonal Antibody

TMPRSS3; ECHOS1; TADG12; Transmembrane protease serine 3; Serine protease TADG-12; Tumor-associated differentially-expressed gene 12 protein

常规抗体

TMPRSS3

Transmembrane protease serine 3

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

64699

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64699

P57727

http://www.uniprot.org/uniprotkb/P57727/entry

140765

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140765

Q8K1T0

http://www.uniprot.org/uniprot/Q8K1T0

The antiserum was produced against synthesized peptide derived from human TMPRSS3. AA range:405-454

TMPRSS3 Polyclonal Antibody detects endogenous levels of TMPRSS3 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

49kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012],

Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas.

Endoplasmic reticulum membrane ; Single-pass type II membrane protein .

disease:Defects in TMPRSS3 are a cause of non-syndromic sensorineural deafness autosomal recessive type 10 (DFNB10) [MIM:605316].,disease:Defects in TMPRSS3 are the cause of non-syndromic sensorineural deafness autosomal recessive type 8 (DFNB8) [MIM:601072]. DFNA8 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,function:Probable protease. Seems to be capable of activating ENaC.,PTM:Undergoes autoproteolytic activation.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 1 SRCR domain.,tissue specificity:Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.