产品名称
TMEM185A Rabbit Polyclonal Antibody
别名
TMEM185A; CXorf13; FAM11A; Transmembrane protein 185A; Protein FAM11A
蛋白名称
Transmembrane protein 185A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84548
Human Swissprot No.
Q8NFB2
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8NFB2/entry
免疫原
The antiserum was produced against synthesized peptide derived from human TMEM185A. AA range:290-339
特异性
TMEM185A Polyclonal Antibody detects endogenous levels of TMEM185A protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is predicted to be a transmembrane protein. This gene is best known for localizing to the CpG island of the fragile site FRAXF. The 5' untranslated region of this gene contains a CGG trinucleotide repeat sequence that normally consists of 7-40 tandem CGG repeats but which can expand to greater than 300 repeats. Methylation of the CpG island leads to transcriptional silencing of this gene, but neither the silencing nor an expanded repeat region appear to manifest itself in a clear phenotypic manner. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Aug 2013],
组织表达
Brain,Iris,Liver,PCR rescued clones,Testis,
细胞定位
Cell projection, dendrite . Membrane ; Multi-pass membrane protein .
功能
similarity:Belongs to the TMEM185 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
