产品名称
TMC8 Rabbit Polyclonal Antibody
别名
TMC8; EVER2; EVIN2; Transmembrane channel-like protein 8; Epidermodysplasia verruciformis protein 2
蛋白名称
Transmembrane channel-like protein 8
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=147138
Human Swissprot No.
Q8IU68
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8IU68/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=217356
Mouse Swissprot No.
Q7TN58
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q7TN58
免疫原
The antiserum was produced against synthesized peptide derived from human TMC8. AA range:601-650
特异性
TMC8 Polyclonal Antibody detects endogenous levels of TMC8 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008],
组织表达
Expressed in placenta, prostate and testis.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
disease:Defects in TMC8 are a cause of epidermodysplasia verruciformis (EV) [MIM:226400]. It is a rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions.,online information:TMC8 mutation db,similarity:Belongs to the TMC family.,tissue specificity:Expressed in placenta, prostate and testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
