产品名称
TLK1 Rabbit Polyclonal Antibody
别名
TLK1; KIAA0137; Serine/threonine-protein kinase tousled-like 1; PKU-beta; Tousled-like kinase 1
蛋白名称
Serine/threonine-protein kinase tousled-like 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9874
Human Swissprot No.
Q9UKI8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UKI8/entry
Mouse Swissprot No.
Q8C0V0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8C0V0
免疫原
The antiserum was produced against synthesized peptide derived from human TLK1. AA range:201-250
特异性
TLK1 Polyclonal Antibody detects endogenous levels of TLK1 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Serine/threonine-protein kinase tousled-like 1 encoded by TLK1 is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene.
组织表达
Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
