产品名称
TLE4 Rabbit Polyclonal Antibody
别名
TLE4; KIAA1261; Transducin-like enhancer protein 4
蛋白名称
Transducin-like enhancer protein 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7091
Human Swissprot No.
Q04727
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q04727/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21888
Mouse Swissprot No.
Q62441
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q62441
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25565
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q07141
免疫原
The antiserum was produced against synthesized peptide derived from human TLE4. AA range:161-210
特异性
TLE4 Polyclonal Antibody detects endogenous levels of TLE4 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
caution:Product of a dubious CDS prediction. Found in the 3'UTR of TLE4. No homolog. Large scale identification of a phosphorylated peptide (PubMed:15302935) would require further confirmation.,function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.,similarity:Belongs to the WD repeat Groucho/TLE family.,similarity:Contains 7 WD repeats.,subunit:Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2.,tissue specificity:In all tissues examined, mostly in brain, and muscle.,
组织表达
In all tissues examined, mostly in brain, and muscle.
功能
caution:Product of a dubious CDS prediction. Found in the 3'UTR of TLE4. No homolog. Large scale identification of a phosphorylated peptide (PubMed:15302935) would require further confirmation.,function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.,similarity:Belongs to the WD repeat Groucho/TLE family.,similarity:Contains 7 WD repeats.,subunit:Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2.,tissue specificity:In all tissues examined, mostly in brain, and muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
