产品名称
TLE2 Rabbit Polyclonal Antibody
别名
TLE2; Transducin-like enhancer protein 2; Enhancer of split groucho-like protein 2; ESG2
蛋白名称
Transducin-like enhancer protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7089
Human Swissprot No.
Q04725
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q04725/entry
Mouse Swissprot No.
Q9WVB2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WVB2
免疫原
The antiserum was produced against synthesized peptide derived from human TLE2. AA range:211-260
特异性
TLE2 Polyclonal Antibody detects endogenous levels of TLE2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.,similarity:Belongs to the WD repeat Groucho/TLE family.,similarity:Contains 6 WD repeats.,subunit:Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5.,tissue specificity:In all tissues examined, mostly in heart, brain, and muscle.,
组织表达
In all tissues examined, mostly in heart, brain, and muscle.
功能
function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.,similarity:Belongs to the WD repeat Groucho/TLE family.,similarity:Contains 6 WD repeats.,subunit:Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5.,tissue specificity:In all tissues examined, mostly in heart, brain, and muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
