产品名称
TIS11D Rabbit Polyclonal Antibody
别名
ZFP36L2; BRF2; ERF2; RNF162C; TIS11D; Zinc finger protein 36; C3H1 type-like 2; ZFP36-like 2; Butyrate response factor 2; EGF-response factor 2; ERF-2; Protein TIS11D
蛋白名称
Zinc finger protein 36 C3H1 type-like 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=678
Human Swissprot No.
P47974
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P47974/entry
Mouse Swissprot No.
P23949
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P23949
免疫原
The antiserum was produced against synthesized peptide derived from human TISD. AA range:207-256
特异性
TIS11D Polyclonal Antibody detects endogenous levels of TIS11D protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008],
组织表达
Expressed mainly in the basal epidermal layer, weakly in the suprabasal epidermal layers (PubMed:27182009). Expressed in epidermal keratinocytes (at protein level) (PubMed:27182009).
细胞定位
Nucleus . Cytoplasm . Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner. .
功能
function:Probable regulatory protein involved in regulating the response to growth factors. RNA-binding protein that binds to 5'UUAUUUAUUU-3' core sequence. Binds to the class II AU-rich element (ARE) in the 3'-UTR of target mRNAs and promotes their deadenylation and degradation.,similarity:Contains 2 C3H1-type zinc fingers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
