产品名称
TIMP-4 Rabbit Polyclonal Antibody
别名
TIMP4; Metalloproteinase inhibitor 4; Tissue inhibitor of metalloproteinases 4; TIMP-4
蛋白名称
Metalloproteinase inhibitor 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7079
Human Swissprot No.
Q99727
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q99727/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=110595
Mouse Swissprot No.
Q9JHB3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JHB3
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=680130
Rat Swissprot Link
http://www.uniprot.org/uniprot/P81556
免疫原
The antiserum was produced against synthesized peptide derived from human TIMP4. AA range:175-224
特异性
TIMP-4 Polyclonal Antibody detects endogenous levels of TIMP-4 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008],
组织表达
Abundant in heart and present at low levels in many other tissues.
功能
function:Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.,similarity:Belongs to the protease inhibitor I35 (TIMP) family.,similarity:Contains 1 NTR domain.,tissue specificity:Abundant in heart and present at low levels in many other tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
