产品名称
TIMAP Rabbit Polyclonal Antibody
别名
PPP1R16B; ANKRD4; KIAA0823; Protein phosphatase 1 regulatory inhibitor subunit 16B; Ankyrin repeat domain-containing protein 4; CAAX box protein TIMAP; TGF-beta-inhibited membrane-associated protein; hTIMAP
蛋白名称
Protein phosphatase 1 regulatory inhibitor subunit 16B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26051
Human Swissprot No.
Q96T49
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96T49/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=228852
Mouse Swissprot No.
Q8VHQ3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VHQ3
免疫原
The antiserum was produced against synthesized peptide derived from human PPP1R16B. AA range:364-413
特异性
TIMAP Polyclonal Antibody detects endogenous levels of TIMAP protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015],
细胞定位
Cell membrane . Cell membrane ; Lipid-anchor . Nucleus . Cell projection . Colocalizes with RPSA/LAMR1 in the cell membrane (PubMed:16263087). Localizes to the perinuclear region (By similarity). Colocalizes with PTEN at the tip of EC projections (PubMed:25007873). .
功能
function:May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.,induction:Inhibited by TGF-beta1.,similarity:Contains 5 ANK repeats.,subunit:Binds PP1.,tissue specificity:Highly expressed in vascular endothelium, CNS, lung, spleen, kidney and testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
