产品名称
Thrombospondin 4 Rabbit Polyclonal Antibody
别名
THBS4; TSP4; Thrombospondin-4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7060
Human Swissprot No.
P35443
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P35443/entry
Mouse Swissprot No.
Q9Z1T2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z1T2
免疫原
The antiserum was produced against synthesized peptide derived from human THBS4. AA range:561-610
特异性
Thrombospondin 4 Polyclonal Antibody detects endogenous levels of Thrombospondin 4 protein.
稀释度
WB 1:500-2000;IHC-p 1:100-500;IF ICC 1:100-500;ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
thrombospondin 4(THBS4) Homo sapiens The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],
细胞定位
Endoplasmic reticulum . Sarcoplasmic reticulum . Secreted . Secreted, extracellular space . Secreted, extracellular space, extracellular matrix .
信号通路
TGF-beta;Focal adhesion;ECM-receptor interaction;
功能
function:Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.,similarity:Belongs to the thrombospondin family.,similarity:Contains 1 TSP C-terminal (TSPC) domain.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,similarity:Contains 4 EGF-like domains.,similarity:Contains 8 TSP type-3 repeats.,subunit:Homopentamer; disulfide-linked.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
