产品名称
THC2 Rabbit Polyclonal Antibody
别名
MASTL; GW; GWL; THC2; Serine/threonine-protein kinase greatwall; GW; GWL; hGWL; Microtubule-associated serine/threonine-protein kinase-like; MAST-L
蛋白名称
Serine/threonine-protein kinase greatwall
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84930
Human Swissprot No.
Q96GX5
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96GX5/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67121
Mouse Swissprot No.
Q8C0P0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8C0P0
免疫原
The antiserum was produced against synthesized peptide derived from human MASTL. AA range:821-870
特异性
THC2 Polyclonal Antibody detects endogenous levels of THC2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Feb 2010],
组织表达
Epithelium,Placenta,
细胞定位
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Nucleus . Cleavage furrow . During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes. Upon mitotic exit moves to the cleavage furrow. .
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in MASTL are the cause of thrombocytopenia type 2 (THC2) [MIM:188000]. Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting.,function:Putative serine/threonine kinase which may be involved in megakaryocyte differentiation.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
