产品名称
TGFβ3 Rabbit Polyclonal Antibody
别名
TGFB3; Transforming growth factor beta-3; TGF-beta-3
蛋白名称
Transforming growth factor beta-3
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7043
Human Swissprot No.
P10600
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P10600/entry
Mouse Swissprot No.
P17125
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P17125
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25717
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q07258
免疫原
The antiserum was produced against synthesized peptide derived from human TGF beta3. AA range:261-310
特异性
TGFβ3 Polyclonal Antibody detects endogenous levels of TGFβ3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic
组织表达
Amygdala,Esophageal,Placenta,Prostate,
细胞定位
[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix .; [Transforming growth factor beta-3]: Secreted .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Cytokine-cytokine receptor interaction;Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;TGF-beta;Intestinal immune network for IgA production;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Chronic myeloid leuke
功能
disease:Defects in TGFB3 are a cause of familial arrhythmogenic right ventricular dysplasia 1 (ARVD1) [MIM:107970]; also known as arrhythmogenic right ventricular cardiomyopathy 1 (ARVC1). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.,function:Involved in embryogenesis and cell differentiation.,online information:TGF beta-3 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
