产品名称
TGFβ RIII Rabbit Polyclonal Antibody
别名
TGFBR3; Transforming growth factor beta receptor type 3; TGF-beta receptor type 3; TGFR-3; Betaglycan; Transforming growth factor beta receptor III; TGF-beta receptor type III
蛋白名称
Transforming growth factor beta receptor type 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7049
Human Swissprot No.
Q03167
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q03167/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21814
Mouse Swissprot No.
O88393
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88393
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29610
Rat Swissprot Link
http://www.uniprot.org/uniprot/P26342
免疫原
The antiserum was produced against synthesized peptide derived from human TGF beta Receptor III. AA range:801-850
特异性
TGFβ RIII Polyclonal Antibody detects endogenous levels of TGFβ RIII protein.
稀释度
WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:5000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010],
组织表达
Blood,Brain,Placenta,Tongue,
细胞定位
Secreted. Secreted, extracellular space. Cell membrane ; Single-pass type I membrane protein . Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.
功能
function:Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.,PTM:Extensively modified by glycosaminoglycan groups (GAG).,similarity:Contains 1 ZP domain.,subcellular location:Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.,subunit:Interacts with TCTEX1D4.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
