产品名称
TGFα Rabbit Polyclonal Antibody
别名
TGFA; Protransforming growth factor alpha
蛋白名称
Protransforming growth factor alpha
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7039
Human Swissprot No.
P01135
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P01135/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21802
Mouse Swissprot No.
P48030
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P48030
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24827
Rat Swissprot Link
http://www.uniprot.org/uniprot/P01134
免疫原
The antiserum was produced against synthesized peptide derived from human TGF alpha. AA range:111-160
特异性
TGFα Polyclonal Antibody detects endogenous levels of TGFα protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],
组织表达
Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines.
细胞定位
[Transforming growth factor alpha]: Secreted, extracellular space.; [Protransforming growth factor alpha]: Cell membrane; Single-pass type I membrane protein.
信号通路
ErbB_HER;Pathways in cancer;Renal cell carcinoma;Pancreatic cancer;Glioma;Prostate cancer;Non-small cell lung cancer;
功能
function:TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.,similarity:Contains 1 EGF-like domain.,subunit:Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
