BD-PT4625-TGase2 Rabbit Polyclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

TGase2 Rabbit Polyclonal Antibody

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产品基本信息

产品货号

BD-PT4625

产品名称

TGase2 Rabbit Polyclonal Antibody

别名

TGM2; Protein-glutamine gamma-glutamyltransferase 2; Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2

类别

常规抗体

基因名称

TGM2

蛋白名称

Protein-glutamine gamma-glutamyltransferase 2

推荐应用

反应种属

Human,Mouse

浓度

1 mg/ml

存储缓冲液

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Human Gene ID

7052

Human Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7052

Human Swissprot No.

P21980

Human Swissprot Link

http://www.uniprot.org/uniprotkb/P21980/entry

Mouse Gene ID

21817

Mouse Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21817

Mouse Swissprot No.

P21981

Mouse Swissprot Link

http://www.uniprot.org/uniprot/P21981

免疫原

The antiserum was produced against synthesized peptide derived from human Transglutaminase 2. AA range:1-50

特异性

TGase2 Polyclonal Antibody detects endogenous levels of TGase2 protein.

稀释度

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

预测分子量

90kD

运输及保存条件

-20°C/1 year

宿主

Polyclonal, Rabbit,IgG

背景介绍

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

组织表达

Brain,Colon adenocarcinoma,Endothelial cell,Kidney,Liver,Lymph node,Ovarian carcino

细胞定位

Cytoplasm, cytosol . Nucleus . Chromosome . Secreted, extracellular space, extracellular matrix . Cell membrane . Mitochondrion . Mainly localizes to the cytosol (PubMed:9575137). Present at much lower level in the nucleus and chromatin (PubMed:9575137). Also secreted via a non-classical secretion pathway to the extracellular matrix (PubMed:27270573). .; [Isoform 2]: Cytoplasm, perinuclear region .

信号通路

Huntington's disease;

功能

catalytic activity:Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).,cofactor:Binds 1 calcium ion per subunit.,disease:Defects in TGM2 are involved in early-onset diabetes type 2.,function:Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.,induction:By retinoic acid.,online information:Tissue transglutaminase entry,similarity:Belongs to the transglutaminase superfamily. Transglutaminase family.,subunit:Monomer.,

期货

现货

纯化

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Transglutaminase 2 Antibody. The picture on the right is blocked with the synthesized peptide.

Western blot analysis of lysates from HUVEC cells, using Transglutaminase 2 Antibody. The lane on the right is blocked with the synthesized peptide.

Western Blot analysis of various cells using TGase2 Polyclonal Antibody

Immunohistochemical analysis of paraffin-embedded Human placenta. 1, Antibody was diluted at 1:200（4°,overnight）. 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200（room temperature, 30min）.

Immunohistochemical analysis of paraffin-embedded Human Endometrium. 1, Antibody was diluted at 1:200（4°,overnight）. 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200（room temperature, 30min）.