产品名称
TFIIIB90-1 Rabbit Polyclonal Antibody
别名
BRF1; BRF; GTF3B; TAF3B2; TAF3C; Transcription factor IIIB 90 kDa subunit; TFIIIB90; hTFIIIB90; B-related factor 1; BRF-1; hBRF; TAF3B2; TATA box-binding protein-associated factor; RNA polymerase III, subunit 2
蛋白名称
Transcription factor IIIB 90 kDa subunit
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2972
Human Swissprot No.
Q92994
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q92994/entry
Mouse Swissprot No.
Q8CFK2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CFK2
免疫原
The antiserum was produced against synthesized peptide derived from human TF3B. AA range:231-280
特异性
TFIIIB90-1 Polyclonal Antibody detects endogenous levels of TFIIIB90-1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011],
组织表达
Brain,Epithelium,PCR rescued clones
功能
function:General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the TFIIB family.,similarity:Contains 1 TFIIB-type zinc finger.,subunit:TFIIIB comprises at least the TATA-binding protein (TBP) and the B-related factor 1 (BRF1/TFIIIB90). Interacts with BDP1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
