产品名称
TESK2 Rabbit Polyclonal Antibody
别名
TESK2; Dual specificity testis-specific protein kinase 2; Testicular protein kinase 2
蛋白名称
Dual specificity testis-specific protein kinase 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10420
Human Swissprot No.
Q96S53
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96S53/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=230661
Mouse Swissprot No.
Q8VCT9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VCT9
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170908
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q924U5
免疫原
The antiserum was produced against synthesized peptide derived from human TESK2. AA range:201-250
特异性
TESK2 Polyclonal Antibody detects endogenous levels of TESK2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
testis-specific kinase 2(TESK2) Homo sapiens This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
组织表达
Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells.
信号通路
Regulation of Microtubule Dynamics
功能
alternative products:Experimental confirmation may be lacking for some isoforms,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,cofactor:Manganese.,enzyme regulation:Activated by autophosphorylation on Ser-219.,function:Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,tissue specificity:Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
