产品名称
TEF Rabbit Polyclonal Antibody
别名
TEF; KIAA1655; Thyrotroph embryonic factor
蛋白名称
Thyrotroph embryonic factor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7008
Human Swissprot No.
Q10587
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q10587/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21685
Mouse Swissprot No.
Q9JLC6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JLC6
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29362
Rat Swissprot Link
http://www.uniprot.org/uniprot/P41224
免疫原
The antiserum was produced against synthesized peptide derived from human TEF. AA range:211-260
特异性
TEF Polyclonal Antibody detects endogenous levels of TEF protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
TEF, PAR bZIP transcription factor(TEF) Homo sapiens This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory
组织表达
Brain,Kidney,Retina,
功能
function:Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'.,induction:Accumulates according to a robust circadian rhythm.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. PAR subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with DBP.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
