产品名称
TDAG51 Rabbit Polyclonal Antibody
别名
PHLDA1; PHRIP; TDAG51; Pleckstrin homology-like domain family A member 1; Apoptosis-associated nuclear protein; Proline- and glutamine-rich protein; PQ-rich protein; PQR protein; Proline- and histidine-rich protein; T-cell death-associated
蛋白名称
Pleckstrin homology-like domain family A member 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22822
Human Swissprot No.
Q8WV24
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8WV24/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21664
Mouse Swissprot No.
Q62392
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q62392
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9QZA1
免疫原
The antiserum was produced against synthesized peptide derived from human PHLA1. AA range:271-320
特异性
TDAG51 Polyclonal Antibody detects endogenous levels of TDAG51 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level).
细胞定位
Cytoplasm . Cytoplasmic vesicle . Nucleus, nucleolus . Colocalizes with intracellular vesicles. .
功能
function:Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.,induction:Induced by homocysteine and other ER stress-inducing reagents. Induced by phorbolester (TPA)/ionomycin, and stimulation of the T-cell receptor (TCR) complex in T-cells.,similarity:Contains 1 PH domain.,subcellular location:Colocalizes with intracellular vesicles.,subunit:Interacts with RPL14, EIF3S7 and PABPC4.,tissue specificity:Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
