产品名称
TCP-1 ε Rabbit Polyclonal Antibody
别名
CCT5; CCTE; KIAA0098; T-complex protein 1 subunit epsilon; TCP-1-epsilon; CCT-epsilon
蛋白名称
T-complex protein 1 subunit epsilon
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22948
Human Swissprot No.
P48643
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P48643/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12465
Mouse Swissprot No.
P80316
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P80316
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=294864
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q68FQ0
免疫原
The antiserum was produced against synthesized peptide derived from human CCT5. AA range:241-290
特异性
TCP-1 ε Polyclonal Antibody detects endogenous levels of TCP-1 ε protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015],
组织表达
Bone marrow,Brain,Cajal-Retzius cell,Embryonic kidney,Fetal brain c
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
功能
disease:Defects in CCT5 are the cause of autosomal recessive sensory neuropathy with spastic paraplegia [MIM:256840]. The disease is characterized by spastic paraplegia and progressive distal sensory neuropathy leading to mutilating ulcerations of the upper and lower limbs.,function:Molecular chaperone; assist the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.,similarity:Belongs to the TCP-1 chaperonin family.,subunit:Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
