产品名称
TCP-1 α Rabbit Polyclonal Antibody
别名
TCP1; CCT1; CCTA; T-complex protein 1 subunit alpha; TCP-1-alpha; CCT-alpha
蛋白名称
T-complex protein 1 subunit alpha
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6950
Human Swissprot No.
P17987
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P17987/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21454
Mouse Swissprot No.
P11983
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P11983
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24818
Rat Swissprot Link
http://www.uniprot.org/uniprot/P28480
免疫原
Synthesized peptide derived from the Internal region of human TCP-1 α.
特异性
TCP-1 α Polyclonal Antibody detects endogenous levels of TCP-1 α protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010],
组织表达
Brain,Cajal-Retzius cell,Colon,Epithelium,Platelet,Testis,
细胞定位
Cytoplasm, cytosol . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
功能
function:Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.,similarity:Belongs to the TCP-1 chaperonin family.,subunit:Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
