产品名称
TCF-3 Rabbit Polyclonal Antibody
别名
TCF7L1; TCF3; Transcription factor 7-like 1; HMG box transcription factor 3; TCF-3
蛋白名称
Transcription factor 7-like 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83439
Human Swissprot No.
Q9HCS4
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9HCS4/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21415
Mouse Swissprot No.
Q9Z1J1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z1J1
免疫原
The antiserum was produced against synthesized peptide derived from human TCF7L1. AA range:321-370
特异性
TCF-3 Polyclonal Antibody detects endogenous levels of TCF-3 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010],
组织表达
Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.
信号通路
Stem cell pathway; Adherens_Junction; Protein_Acetylation
功能
domain:The putative Groucho interaction domain between the N-terminal CTNNB1 binding domain and the HMG-box is necessary for repression of the transactivation mediated by TCF7L1 and CTNNB1.,function:Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.,similarity:Belongs to the TCF/LEF family.,similarity:Contains 1 HMG box DNA-binding domain.,subunit:Binds the armadillo repeat of CTNNB1 and forms a stable complex.,tissue specificity:Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
