产品名称
TCEAL1 Rabbit Polyclonal Antibody
别名
TCEAL1; SIIR; Transcription elongation factor A protein-like 1; TCEA-like protein 1; Nuclear phosphoprotein p21/SIIR; Transcription elongation factor S-II protein-like 1
蛋白名称
Transcription elongation factor A protein-like 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9338
Human Swissprot No.
Q15170
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q15170/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=237052
Mouse Swissprot No.
Q921P9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q921P9
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=302593
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q5PPP3
免疫原
The antiserum was produced against synthesized peptide derived from human TCEAL1. AA range:91-140
特异性
TCEAL1 Polyclonal Antibody detects endogenous levels of TCEAL1 protein.
稀释度
WB 1:500 - 1:2000.IHC-p:1:50-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008],
组织表达
Expressed in all tissues examined. Highly expressed in heart, ovary, prostate and skeletal muscle. Moderately expressed in brain, placenta, testis and small intestine. Weakly expressed in lung, liver and spleen. Expressed in several cancer cell lines.
功能
function:May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly.,PTM:Phosphorylation of Ser-36 and Ser-37 is critical for transcriptional repression.,similarity:Belongs to the TFS-II family. TFA subfamily.,tissue specificity:Expressed in all tissues examined. Highly expressed in heart, ovary, prostate and skeletal muscle. Moderately expressed in brain, placenta, testis and small intestine. Weakly expressed in lung, liver and spleen. Expressed in several cancer cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
