产品名称
TBX3 Rabbit Polyclonal Antibody
别名
TBX3; T-box transcription factor TBX3; T-box protein 3
蛋白名称
T-box transcription factor TBX3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6926
Human Swissprot No.
O15119
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O15119/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21386
Mouse Swissprot No.
P70324
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P70324
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=353305
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q7TST9
免疫原
The antiserum was produced against synthesized peptide derived from human TBX3. AA range:301-350
特异性
TBX3 Polyclonal Antibody detects endogenous levels of TBX3 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008],
功能
disease:Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS) [MIM:181450]. UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands.,function:Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation.,similarity:Contains 1 T-box DNA-binding domain.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
