产品名称
TADA2L Rabbit Polyclonal Antibody
别名
TADA2A; TADA2L; KL04P; Transcriptional adapter 2-alpha; Transcriptional adapter 2-like; ADA2-like protein
蛋白名称
Transcriptional adapter 2-alpha
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6871
Human Swissprot No.
O75478
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O75478/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=217031
Mouse Swissprot No.
Q8CHV6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CHV6
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=360581
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q6AYE3
免疫原
The antiserum was produced against synthesized peptide derived from human ADA2L. AA range:206-255
特异性
TADA2L Polyclonal Antibody detects endogenous levels of TADA2L protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009],
组织表达
Expressed in all tissues, but most abundantly in testis.
细胞定位
Nucleus . Chromosome .
功能
function:Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling (By similarity). Required for the function of some acidic activation domains, which activate transcription from a distant site.,similarity:Contains 1 SANT domain.,similarity:Contains 1 SWIRM domain.,subunit:Interacts with GCN5 and NR3C1. Associated with the P/CAF protein in the PCAF complex. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP.,tissue specificity:Expressed in all tissues, but most abundantly in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
