产品名称
SYP Rabbit Polyclonal Antibody
别名
SYP; Synaptophysin; Major synaptic vesicle protein p38
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6855
Human Swissprot No.
P08247
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P08247/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20977
Mouse Swissprot No.
Q62277
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q62277
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24804
Rat Swissprot Link
http://www.uniprot.org/uniprot/P07825
免疫原
The antiserum was produced against synthesized peptide derived from human Synaptophysin. AA range:101-150
特异性
SYP Polyclonal Antibody detects endogenous levels of SYP protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR). [provided by RefSeq, Aug 2011],
组织表达
Expressed in the brain, with expression in the hippocampus, the neuropil in the dentate gyrus, where expression is higher in the outer half of the molecular layer than in the inner half, and in the neuropil of CA4 and CA3 (PubMed:8838578). Expressed in the putamen (at protein level) (PubMed:17296554).
细胞定位
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Cell junction, synapse, synaptosome .
功能
domain:The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.,function:Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane.,online information:Synaptophysin entry,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the synaptophysin/synaptobrevin family.,similarity:Contains 1 MARVEL domain.,subunit:Homohexamer or homotetramer.,tissue specificity:Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
