产品名称
Synuclein-β Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6620
Human Swissprot No.
Q16143
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q16143/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=104069
Mouse Swissprot No.
Q91ZZ3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91ZZ3
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=113893
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q63754
免疫原
The antiserum was produced against synthesized peptide derived from human Synuclein beta. AA range:85-134
特异性
Synuclein-β Polyclonal Antibody detects endogenous levels of Synuclein-β protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
组织表达
Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
功能
disease:Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCB is found in spheroids but not in inclusions.,function:Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a TP53/p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.,PTM:Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.,similarity:Belongs to the synuclein family.,tissue specificity:Expressed predominantly in brain; concentrated in presynaptic nerve terminals.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
