产品名称
Synaptotagmin XI Rabbit Polyclonal Antibody
别名
SYT11; KIAA0080; Synaptotagmin-11; Synaptotagmin XI; SytXI
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23208
Human Swissprot No.
Q9BT88
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9BT88/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=229521
Mouse Swissprot No.
Q9R0N3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9R0N3
Rat Swissprot Link
http://www.uniprot.org/uniprot/O08835
免疫原
The antiserum was produced against synthesized peptide derived from human SYT11. AA range:181-230
特异性
Synaptotagmin XI Polyclonal Antibody detects endogenous levels of Synaptotagmin XI protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
synaptotagmin 11(SYT11) Homo sapiens This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010],
组织表达
Amygdala,Bone marrow,Brain,Lymph,
细胞定位
Cytoplasmic vesicle membrane ; Single-pass membrane protein . Perikaryon . Golgi apparatus, trans-Golgi network membrane ; Single-pass membrane protein . Recycling endosome membrane ; Single-pass membrane protein . Lysosome membrane ; Single-pass membrane protein . Cytoplasmic vesicle, phagosome . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse, postsynaptic density . Recycling endosome membrane ; Single-pass membrane protein . Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Single-pass membrane protein . Perikaryon . Localized in vesicles that travels in axonal and dendritic shafts in both anterograde and retrograde directions. In macrophages and microglia, recruited in phagosomes at early stages of phagocytosis (By similarity). Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients (PubMed:12925569). .
功能
cofactor:Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.,function:May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.,PTM:Ubiquitinated and targeted to the proteasome complex for degradation.,similarity:Belongs to the synaptotagmin family.,similarity:Contains 2 C2 domains.,subcellular location:In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients.,subunit:Homodimer. Can also form heterodimers (By similarity). Interacts with PARK2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
