产品名称
SURF-1 Rabbit Polyclonal Antibody
别名
SURF1; SURF-1; Surfeit locus protein 1
蛋白名称
Surfeit locus protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6834
Human Swissprot No.
Q15526
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q15526/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20930
Mouse Swissprot No.
P09925
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P09925
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64463
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9QXU2
免疫原
The antiserum was produced against synthesized peptide derived from human SURF1. AA range:171-220
特异性
SURF-1 Polyclonal Antibody detects endogenous levels of SURF-1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency. [provided by RefSeq, Jul 2008],
组织表达
Colon,Kidney,Skin,Stomach,
细胞定位
Mitochondrion inner membrane ; Multi-pass membrane protein .
功能
disease:Defects in SURF1 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions that is commonly associated with systemic cytochrome c oxidase (COX) deficiency.,function:Probably involved in the biogenesis of the COX complex.,similarity:Belongs to the SURF1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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