产品名称
Strad Rabbit Polyclonal Antibody
别名
STRADA; LYK5; STRAD; STE20-related kinase adapter protein alpha; STRAD alpha; STE20-related adapter protein; Serologically defined breast cancer antigen NY-BR-96
蛋白名称
STE20-related kinase adapter protein alpha
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=92335
Human Swissprot No.
Q7RTN6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q7RTN6/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=72149
Mouse Swissprot No.
Q3UUJ4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3UUJ4
免疫原
The antiserum was produced against synthesized peptide derived from human STRAD. AA range:11-60
特异性
Strad Polyclonal Antibody detects endogenous levels of Strad protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009],
组织表达
Lymph node,Mammary tumor,Synovial membrane tissue,Teratocarcinoma,U
细胞定位
Nucleus . Cytoplasm .
功能
disease:Deletions involving STRADA are the cause of polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome (PMSE) [MIM:611087]. Affected children have large heads, infantile-onset intractable multifocal seizures and severe psychomotor retardation. Neuropathological studies reveal megalencephaly, ventriculomegaly, cytomegaly and extensive vacuolization and astrocytosis of white matter.,domain:The protein kinase domain is predicted to be catalytically inactive.,function:Pseudokinase which, in complex with CAB39, binds to and activates STK11. Relocates STK11 from the nucleus to the cytoplasm. Plays an essential role in STK11-mediated G1 cell cycle arrest.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
