产品名称
StIp1 Rabbit Polyclonal Antibody
别名
ELP2; STATIP1; Elongator complex protein 2; ELP2; SHINC-2; STAT3-interacting protein 1; StIP1
蛋白名称
Elongator complex protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55250
Human Swissprot No.
Q6IA86
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q6IA86/entry
Mouse Swissprot No.
Q91WG4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91WG4
免疫原
The antiserum was produced against synthesized peptide derived from human ELP2. AA range:771-820
特异性
StIp1 Polyclonal Antibody detects endogenous levels of StIp1 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin. [provided by RefSeq, May 2016],
组织表达
Hematopoietic,Liver,Ovary,Uterus,
细胞定位
Cytoplasm . Nucleus .
功能
function:Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.,function:Regulates the ligand-dependent activation of STAT3.,similarity:Belongs to the WD repeat ELP2 family.,similarity:Contains 14 WD repeats.,subunit:Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with STAT3 and JAKs.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
