产品名称
STEAP2 Rabbit Polyclonal Antibody
别名
STEAP2; PCANAP1; STAMP1; Metalloreductase STEAP2; Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; PUMPCn; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1
蛋白名称
Metalloreductase STEAP2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=261729
Human Swissprot No.
Q8NFT2
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8NFT2/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=74051
Mouse Swissprot No.
Q8BWB6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BWB6
免疫原
The antiserum was produced against synthesized peptide derived from human STEA2. AA range:431-480
特异性
STEAP2 Polyclonal Antibody detects endogenous levels of STEAP2 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
STEAP2 metalloreductase(STEAP2) Homo sapiens This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
组织表达
Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.
细胞定位
Endosome membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein .
功能
cofactor:FAD.,function:Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.,similarity:Belongs to the STEAP family.,similarity:Contains 1 ferric oxidoreductase domain.,tissue specificity:Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
