BD-PT4432

ST5 Rabbit Polyclonal Antibody

ST5; DENND2B; HTS1; Suppression of tumorigenicity 5 protein; DENN domain-containing protein 2B; HeLa tumor suppression 1

常规抗体

ST5

Suppression of tumorigenicity 5 protein

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

6764

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6764

P78524

http://www.uniprot.org/uniprotkb/P78524/entry

76954

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=76954

Q924W7

http://www.uniprot.org/uniprot/Q924W7

The antiserum was produced against synthesized peptide derived from human ST5. AA range:411-460

ST5 Polyclonal Antibody detects endogenous levels of ST5 protein.

WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

126kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008],

Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level).

[Isoform 1]: Cytoplasm, cell cortex . Cell membrane . Recycling endosome . Colocalizes with RAB13 and ITSN1 at cytoplasmic vesicles that are most likely recycling endosomes. Colocalizes with the cortical actin cytoskeleton. .

function:May be involved in cytoskeletal organization and tumorgenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth.,similarity:Contains 1 dDENN domain.,similarity:Contains 1 DENN domain.,similarity:Contains 1 uDENN domain.,subunit:Isoform 1 interacts with the SH3 domain of ABL1.,tissue specificity:Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level).,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.